Antitumorigenic potential of STAT3 alternative splicing modulation
نویسندگان
چکیده
منابع مشابه
Antitumorigenic potential of STAT3 alternative splicing modulation.
Signal transducer and activator of transcription 3 (STAT3) plays a central role in the activation of multiple oncogenic pathways. Splicing variant STAT3β uses an alternative acceptor site within exon 23 that leads to a truncated isoform lacking the C-terminal transactivation domain. Depending on the context, STAT3β can act as a dominant-negative regulator of transcription and promote apoptosis....
متن کاملRole of Aberrant Alternative Splicing in Cancer
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
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presentations Zammarchi F. et al. Redirection of STAT3 alternative splicing: a novel anti-tumoral approach. 3nd annual postdoctoral research symposium, Memorial-Sloan Kettering Cancer Center, New York, U.S.A. (2009). Zammarchi F. et al. Modulation of STAT3 alternative splicing as a tool to dissect its antitumorigenic potential. RNA Society’s 2010 Annual Meeting, Seattle, (2010). Zammarchi F. et...
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Alternative splicing is an important mechanism that contributes to expanding protein diversity by generating multiple protein isoforms from a single gene. We have previously reported computational approach to infer alternative splicing patterns from Mus musculus full-length cDNA clones and microarray data [4]. Although we have predicted a large number of unreported splice variants, general mech...
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Huntington's disease (HD) is caused by a genetically mutated huntingtin (mHtt) protein with expanded polyQ stretch, which impairs cytosolic sequestration of the repressor element-1 silencing transcription factor (REST), resulting in excessive nuclear REST and subsequent repression of neuronal genes. We recently demonstrated that REST undergoes extensive, context-dependent alternative splicing, ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2011
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1108482108